Role of interleukin 32 in human immunodeficiency virus reactivation and its link to human immunodeficiency virus-herpes simplex virus coinfection
Authors: Mesquita, P.M., Preston-Hurlburt, P., Keller, M.J., Vudattu, N., Espinoza, L., Altrich, M., Anastos, K., Herold, K.C., Herold, B.C.,
The human immunodeficiency virus (HIV) epidemic is fueled by coinfections, which may promote HIV acquisition, replication, and the establishment or expansion of viral reservoirs. One of the most significant coinfections is herpes simplex virus type 2 (HSV-2) [1, 2]. Herpes simplex virus type 2–seropositive (HSV-2+) individuals have an increased risk of HIV acquisition, and dually-infected (HIV+/HSV-2+) individuals are more likely to transmit HIV to their partner(s) or from mother to child [2–6]. The high prevalence of HSV-2 in sub–Saharan Africa has been suggested to contribute more than other biological and behavioral factors to HIV transmission...View More
