A randomized, double-blind, placebo-controlled of vitamin D3 for Irish children with asthma
Authors: Kerley, C., Hutchinson, K., Greally, P., Couglan, D., Elnazir, B.,
We have recently reviewed that many mechanisms( Reference Kerley, Elnazir, Faul and Cormican1 ) and human studies( Reference Kerley, Elnazir, Faul and Cormican2 ) linking vitamin D deficiency (VDD) to asthma. Associations between vitamin D and both asthma/allergy appear stronger in children than adults( Reference Goleva, Searing and Jackson3 ), with some even suggesting that childhood asthma may be caused by VDD( Reference Litonjua and Weiss4 ). Conversely, an alternative hypothesis suggests increased vitamin D status is associated with increased asthma/allergy incidence and severity( Reference Wjst5 ).
In line with these opposing theories, several recent randomized trials of vitamin D supplementation in paediatric asthma have demonstrated inconsistent results. We wanted to assess the effects of vitamin D3 supplementation on subjective asthma measures, lung function, biomarkers of inflammation/allergy and self-reported exacerbation/infection rate in Caucasian, asthmatic children residing at high latitude over the winter season... View Here
